[Conservative loco-regional treatment of soft tissue sarcoma in adults after induction chemotherapy].

Abstract

Between June, 1979 and December, 1983, 23 adult patients with non-metastatic soft tissue sarcoma were treated with induction chemotherapy since local spread precluded primary conservative surgery. Eighteen patients received a combined cyclophosphamide, vincristine, adriamycin and dacarbazine treatment and 5, a combined adriamycin, cis-platinum and vindesine treatment. Both drug combinations exhibited toxic effects, notably on blood and digestive tract. However, tumoral volume was reduced by 50 p. cent or more in 14/23 patients, including 2 complete remissions; the course of the disease remained unchanged under treatment in only 3 cases. Chemotherapy facilitated surgical excision in 14 patients, and subsequent radiotherapy resulted in complete remission in 13 of these. None of the 13 patients relapsed during a mean follow-up period of 12 months (range: 3 to 48 months). Among the 9 patients who could not be operated upon, 5 benefited from radiotherapy with satisfactory local control, but only one still remains in complete remission. Thus, induction chemotherapy made it possible to achieve local control in two-thirds of patients with locally advanced sarcoma. However, a more prolonged follow-up is necessary to confirm that these results are long-lasting and to determine the effects of chemotherapy, if any, on the metastatic potential of these tumours.

• Authors: D Marée, C Hocke, N B Bui, J M Coindre, P Tramond, A Avril, P Mage, J Chauvergne, P Richaud
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 14 Issue 19 Pg. 1069-72 (May 11 1985) ISSN: 0755-4982 [Print] France
• Vernacular Title: Traitement loco-régional conservateur des sarcomes des tissus mous chez l'adulte après chimiothérapie d'induction.
• PMID: 3158961 (Publication Type: English Abstract, Journal Article)

Chemical References

• Vincristine
• Vinblastine
• Dacarbazine
• Doxorubicin
• Cyclophosphamide
• Cisplatin
• Vindesine

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Cisplatin (administration & dosage)
• Combined Modality Therapy
• Cyclophosphamide (administration & dosage)
• Dacarbazine (administration & dosage)
• Doxorubicin (administration & dosage)
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Sarcoma (drug therapy, radiotherapy, surgery)
• Soft Tissue Neoplasms (drug therapy, radiotherapy, surgery)
• Vinblastine (administration & dosage, analogs & derivatives)
• Vincristine (administration & dosage)
• Vindesine