Il-6 Involvement in pain, fatigue and mood disorders in rheumatoid arthritis and the effects of Il-6 inhibitor sarilumab.

Abstract

Interleukin 6 (IL-6) is a pleiotropic cytokine that plays a role in the neuroendocrine system, insulin resistance, lipid metabolism, vascular disease, mitochondrial activities, neuropsychological behaviour, and also mediates communications between the immune and central nervous system (CNS). Treatment with anti-IL-6 or anti-IL-6R agents seems to alleviate allodynia and hyperalgesia, so it may be a valid option when treating the many conditions involving pathological pain as rheumatoid arthritis.

• Authors: Fabiola Atzeni, Valeria Nucera, Ignazio Francesco Masala, Piercarlo Sarzi-Puttini, Gianluca Bonitta
• Journal: Pharmacological research (Pharmacol Res) Vol. 149 Pg. 104402 (11 2019) ISSN: 1096-1186 [Electronic] Netherlands
• PMID: 31536783 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2019 Elsevier Ltd. All rights reserved.

Chemical References

• Antibodies, Monoclonal, Humanized
• Interleukin-6
• sarilumab

Topics

• Antibodies, Monoclonal, Humanized (therapeutic use)
• Arthritis, Rheumatoid (complications, drug therapy, immunology)
• Fatigue (complications, drug therapy, immunology)
• Humans
• Interleukin-6 (antagonists & inhibitors)
• Male
• Mood Disorders (complications, drug therapy, immunology)
• Pain (complications, drug therapy, immunology)
• Randomized Controlled Trials as Topic
• Treatment Outcome