Abstract | OBJECTIVES: MATERIALS AND METHODS: RESULTS: We identified 34 differentially expressed genes that distinguish the responders from the non-responders. Pathway analysis using these genes revealed alteration of multiple pathways between the two groups. Of these 34 genes, 24 distinguished between these two groups. Additionally, 16 gene pairs were associated with response to induction therapy. CONCLUSION: We identified genes predictive of SNUC response to induction chemotherapy and pathways potentially associated with treatment outcome. This is the first report of identification of predictive biomarkers for response of SNUC to induction chemotherapy, and it may help us develop therapeutic strategies to improve the treatment outcomes of non-responders.
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Authors | Yoko Takahashi, Frederico O Gleber-Netto, Diana Bell, Dianna Roberts, Tong-Xin Xie, Ahmed S Abdelmeguid, Curtis Pickering, Jeffrey N Myers, Ehab Y Hanna |
Journal | Oral oncology
(Oral Oncol)
Vol. 97
Pg. 56-61
(10 2019)
ISSN: 1879-0593 [Electronic] England |
PMID | 31421472
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2019 Elsevier Ltd. All rights reserved. |
Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(genetics)
- Carcinoma
(drug therapy, genetics, pathology)
- Combined Modality Therapy
(methods)
- Female
- Humans
- Induction Chemotherapy
(methods)
- Male
- Maxillary Sinus Neoplasms
(drug therapy, genetics, pathology)
- Middle Aged
- Prognosis
- Treatment Outcome
- Young Adult
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