Prostacyclin Analogue-Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats.

Abstract

Intravenously injected ONO-1301-containing nanoparticles (ONO-1301NPs), unlike an ONO-1301 solution, selectively accumulated in the ischemia/reperfusion (I/R)-injured myocardium of rats and contributed to the prolonged retention of ONO-1301 in the targeted myocardial tissue. In the ischemic area, proangiogenic cytokines were up-regulated and inflammatory cytokines were down-regulated upon ONO-1301NP administration. Consequently, ONO-1301NP-injected rats exhibited a smaller infarct size, better-preserved capillary networks, and a better-preserved myocardial blood flow at 24 h after I/R injury, compared with those in vehicle-injected or ONO-1301 solution-injected rats. ONO-1301NPs attenuate the myocardial I/R injury via proangiogenic and anti-inflammatory effects of the drug.

• Authors: Shin Yajima, Shigeru Miyagawa, Satsuki Fukushima, Yoshiki Sakai, Hiroko Iseoka, Akima Harada, Kayako Isohashi, Genki Horitsugi, Yuki Mori, Motoko Shiozaki, Hirotatsu Ohkawara, Ryoto Sakaniwa, Jun Hatazawa, Yoshichika Yoshioka, Yoshiki Sawa
• Journal: JACC. Basic to translational science (JACC Basic Transl Sci) Vol. 4 Issue 3 Pg. 318-331 (Jun 2019) ISSN: 2452-302X [Electronic] United States
• PMID: 31312756 (Publication Type: Journal Article)