Interleukin 28 is a potential therapeutic target for sepsis.

Abstract

Identification of new therapeutic targets for the treatment of sepsis is imperative. We report here that cytokine IL-28 (IFN-λ) levels were elevated in clinical and experimental sepsis. Neutralization of IL-28 protected mice from lethal sepsis induced by cecal ligation and puncture (CLP), which was associated with improved bacterial clearance and enhanced neutrophil infiltration. Conversely, administration of recombinant IL-28 aggravated mortality, facilitated bacterial dissimilation and limited neutrophil recruitment, in the model of sepsis induced by CLP. This study defines IL-28 as a detrimental mediator during sepsis and identifies a potential therapeutic target for the immune therapy in sepsis.

• Authors: Qin Luo, Yi Liu, Shuang Liu, Yibing Yin, Banglao Xu, Ju Cao
• Journal: Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 205 Pg. 29-34 (08 2019) ISSN: 1521-7035 [Electronic] United States
• PMID: 31121287 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• Antibodies, Neutralizing
• Cytokines
• interferon-lambda, human
• IL28A protein, mouse
• Interleukins
• interferon-lambda protein, mouse

Topics

• Adult
• Aged
• Animals
• Antibodies, Neutralizing (pharmacology)
• Cecum (surgery)
• Cytokines (antagonists & inhibitors, pharmacology)
• Disease Models, Animal
• Female
• Humans
• Interleukins (antagonists & inhibitors, immunology, pharmacology)
• Intestinal Perforation
• Male
• Mice
• Middle Aged
• Molecular Targeted Therapy
• Mortality
• Neutrophil Infiltration (drug effects, immunology)
• Sepsis (immunology)