Abstract | BACKGROUND: OBJECTIVES: To assess the serum levels of cytokines secreted by Th1 (IL-2, IFN-γ), Th2 (IL-4), Th17 (IL-23, IL-17A), and Treg (IL-10) pathways in patients of active AA and to correlate their levels with the severity of the disease. MATERIAL AND METHODS: RESULTS: Serum levels of cytokines IL-2, IFN-γ, IL-17A, and IL-10 were significantly raised while serum levels of IL-23 were nonsignificantly raised in AA patients as compared to controls. The levels of IL-4 were significantly lower in AA patients as compared to controls. (P < 0.05). Also, significant positive correlation was found between increase in SALT Score and serum levels of IL-2, IL-17A, and IL-23. (P < 0.05). CONCLUSION: Th1 and Th17 pathways play a central role in the initiation and progression of AA, while Th2 pathway is suppressed in active AA. Treg pathway may be opposing Th1 and Th17 pathway and causes disease localization. The instant study lays the groundwork for understanding the pathogenesis of AA and suggests the role of implicated cytokines as potential therapeutic targets and as biomarkers of disease activity.
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Authors | Ram Kishan Gautam, Yogita Singh, Aastha Gupta, Pooja Arora, Ananta Khurana, Anubhuti Chitkara |
Journal | Journal of cosmetic dermatology
(J Cosmet Dermatol)
Vol. 19
Issue 1
Pg. 234-240
(Jan 2020)
ISSN: 1473-2165 [Electronic] England |
PMID | 31087753
(Publication Type: Journal Article, Observational Study)
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Copyright | © 2019 Wiley Periodicals, Inc. |
Chemical References |
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Topics |
- Adolescent
- Adult
- Alopecia Areata
(blood, immunology)
- Biomarkers
(blood)
- Case-Control Studies
- Cross-Sectional Studies
- Cytokines
(blood, metabolism)
- Disease Progression
- Female
- Healthy Volunteers
- Humans
- Male
- Prospective Studies
- Scalp
- T-Lymphocytes, Regulatory
(immunology, metabolism)
- Th1 Cells
(immunology, metabolism)
- Th17 Cells
(immunology, metabolism)
- Th2 Cells
(immunology, metabolism)
- Young Adult
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