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Nanoparticle-microRNA-146a-5p polyplexes ameliorate diabetic peripheral neuropathy by modulating inflammation and apoptosis.

Abstract
Nontoxic and nonimmunogenic nanoparticles play an increasingly important role in the application of pharmaceutical nanocarriers. The pathogenesis of diabetic peripheral neuropathy (DPN) has been extensively studied. However, the role of microRNAs in DPN remains to be clarified. We verified in vitro that miR-146a-5p mimics inhibited the expression of proinflammatory cytokines and apoptosis. Then, we explored the protective effect of nanoparticle-miRNA-146a-5p polyplexes (nano-miR-146a-5p) on DPN rats. We demonstrated that nano-miR-146a-5p improved nerve conduction velocity and alleviated the morphological damage and demyelination of the sciatic nerve of DPN rats. The expression of the inflammatory cytokines, caspase-3, and cleaved caspase-3 in the sciatic nerve was inhibited by nano-miR-146a-5p. Additionally, nano-miR-146a-5p increased the expression of myelin basic protein. These results all indicated that nano-miR-146a-5p had a protective effect on peripheral nerves in the DPN rat model, which may occur through the regulation of the inflammatory response and apoptosis.
AuthorsQiong Luo, Yonghao Feng, Yangmei Xie, Yiye Shao, Men Wu, Xiaolin Deng, Wei-En Yuan, Yinghui Chen, Xiaohong Shi
JournalNanomedicine : nanotechnology, biology, and medicine (Nanomedicine) Vol. 17 Pg. 188-197 (04 2019) ISSN: 1549-9642 [Electronic] United States
PMID30721753 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
Chemical References
  • MIRN146a microRNA, rat
  • MicroRNAs
Topics
  • Animals
  • Apoptosis
  • Cell Line
  • Diabetes Mellitus, Experimental (complications, genetics, pathology)
  • Diabetic Neuropathies (genetics, pathology, therapy)
  • Genetic Therapy
  • Inflammation (therapy)
  • MicroRNAs (therapeutic use)
  • Nanoparticles (therapeutic use)
  • Rats
  • Sciatic Nerve (metabolism, pathology)

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