Abstract | AIMS/INTRODUCTION: MATERIALS AND METHODS: Type 2 diabetes mellitus (Otsuka Long-Evans Tokushima Fatty rats [OLETF]) and control (Long-Evans Tokushima Otsuka rats [LETO]) were treated with canagliflozin, an SGLT2 inhibitor, for 2 weeks. Renal tissues were analyzed at 12 h after MI with or without preoperative fasting. RESULTS: CONCLUSIONS: The findings suggest that SGLT2 inhibitor treatment with a fasting period protects kidneys from MI-induced cardiorenal syndrome, possibly by β-hydroxybutyrate-mediated reduction of NOXs and oxidative stress, in type 2 diabetic rats.
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Authors | Yukishige Kimura, Atsushi Kuno, Masaya Tanno, Tatsuya Sato, Kouhei Ohno, Satoru Shibata, Kei Nakata, Hirohito Sugawara, Koki Abe, Yusuke Igaki, Toshiyuki Yano, Takayuki Miki, Tetsuji Miura |
Journal | Journal of diabetes investigation
(J Diabetes Investig)
Vol. 10
Issue 4
Pg. 933-946
(Jul 2019)
ISSN: 2040-1124 [Electronic] Japan |
PMID | 30663266
(Publication Type: Journal Article)
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Copyright | © 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Sodium-Glucose Transporter 2 Inhibitors
- Canagliflozin
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Topics |
- Acute Kidney Injury
(etiology, prevention & control)
- Animals
- Canagliflozin
(pharmacology)
- Cardio-Renal Syndrome
(etiology, prevention & control)
- Diabetes Mellitus, Type 2
(complications)
- Lipid Peroxidation
(drug effects)
- Male
- Myocardial Infarction
(etiology, prevention & control)
- Oxidative Stress
(drug effects)
- Rats
- Rats, Inbred OLETF
- Sodium-Glucose Transporter 2 Inhibitors
(pharmacology)
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