T-bet transcription factor in cardiovascular disease: Attenuation or inflammation factor?

Abstract

T-bet is a major transcription factor increasing inflammatory responses in the immune system. Recently, it has been shown that this factor leads to inflammation in cardiovascular disease (CVD). In this study, we examine the dual role of T-bet in inducing and suppressing inflammatory reactions as well as angiogenesis induction due to inflammatory cytokines in CVD. Relevant literature was identified by a Pubmed search (1992-2018) of English-language papers using the terms "T-bet," "Cardiovascular disease," "Immune response," and "Angiogenesis." Although T-bet causes differentiation of Th1 cells and activation of immune cells such as NK and DC, it suppresses inflammatory responses and replaces damaged vessels with new ones by activating regulatory T-cells and stimulating angiogenesis. It can be stated that T-bet acts as double-edged sword. Therefore, the identification of pathways that can increase the function of T-bet in activating Tregs and inducing angiogenesis might be used as a new therapeutic option in future investigations.

• Authors: Habib Haybar, Hadi Rezaeeyan, Mohammad Shahjahani, Reza Shirzad, Najmaldin Saki
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 234 Issue 6 Pg. 7915-7922 (06 2019) ISSN: 1097-4652 [Electronic] United States
• PMID: 30536907 (Publication Type: Journal Article, Review)
• Copyright: © 2018 Wiley Periodicals, Inc.

Chemical References

• Cytokines
• T-Box Domain Proteins
• T-box transcription factor TBX21

Topics

• Cardiovascular Diseases (genetics, immunology, pathology)
• Cell Differentiation (genetics)
• Cytokines (genetics, immunology)
• Gene Expression Regulation (immunology)
• Humans
• Inflammation (genetics, immunology, pathology)
• Neovascularization, Pathologic (genetics, immunology)
• Signal Transduction (genetics)
• T-Box Domain Proteins (genetics)
• T-Lymphocytes, Regulatory (immunology)