Ototoxicity in locally advanced head and neck cancer patients treated with induction chemotherapy followed by intermediate or high-dose cisplatin-based chemoradiotherapy.

Abstract

BACKGROUND:

This study evaluated ototoxicity in locally advanced head and neck cancer patients treated in the CONDOR study with docetaxel/cisplatin/5-fluorouracil (TPF) followed by conventional radiotherapy with concomitant cisplatin 100 mg/m2 on days 1, 22, and 43 (cis100+RT) versus accelerated radiotherapy with concomitant cisplatin weekly 40 mg/m2 (cis40+ART).

METHODS:

Sixty-two patients were treated in this study. Audiometry was performed at baseline, during TPF, before start of chemoradiotherapy, and 1, 4, 8, and 12 months after treatment.

RESULTS:

A complete dataset of audiometric data was available of 12 patients treated with high-dose cisplatin and of 11 patients treated with intermediate-dose cisplatin. Patients in the high-dose group showed significant more hearing loss than in the intermediate group at 4 kHz ([z = 1.98; P = .04] and 8 kHz [z = 2.07; P < .03]). Interindividual variation was high in both groups.

CONCLUSION:

After induction TPF, more ototoxicity was observed in chemoradiotherapy with cis100+RT than after chemoradiotherapy with cis40+ART.

• Authors: Chantal M L Driessen, Joop Leijendeckers, Ad Snik, Winette T A van der Graaf, Jan Paiul de Boer, Hans Gelderblom, Johannes H A M Kaanders, Robert Takes, Carla M L van Herpen
• Journal: Head & neck (Head Neck) Vol. 41 Issue 2 Pg. 488-494 (02 2019) ISSN: 1097-0347 [Electronic] United States
• PMID: 30536479 (Publication Type: Clinical Trial, Phase II, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2018 Wiley Periodicals, Inc.

Chemical References

• Antineoplastic Agents
• Docetaxel
• Cisplatin
• Fluorouracil

Topics

• Adult
• Antineoplastic Agents (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols
• Chemoradiotherapy
• Cisplatin (therapeutic use)
• Docetaxel (therapeutic use)
• Female
• Fluorouracil (therapeutic use)
• Head and Neck Neoplasms (drug therapy, pathology, radiotherapy)
• Humans
• Induction Chemotherapy
• Male
• Middle Aged
• Netherlands
• Ototoxicity (diagnosis, epidemiology)