Ameliorative Effect of Dangguibuxue Decoction against Cyclophosphamide-Induced Heart Injury in Mice.

Abstract

Dangguibuxue decoction (DBD), a kind of Chinese herbal medicine, has been widely used to treat blood deficiency disease in China. In this experiment, we studied the effects of the Dangguibuxue decoction (DBD) on the myocardial injury induced by cyclophosphamide in mice. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), and lactic dehydrogenase (LDH) in serum were detected by commercial kits. Total white blood cell (WBCs), platelets, and cytokines pathological changes of heart tissue were also examined. In addition, the protein levels of the NF-кB pathway were detected to reveal its mechanism. The results showed that DBD significantly decreased the levels of ALT, AST, CK, and LDH and increased WBCs in CTX-induced mice. In addition, DBD significantly alleviated pathological changes of heart tissue. DBD significantly reduced the protein expressions of NF-кB signaling pathway. In summary, DBD can be considered an effective drug to alleviate CTX-induced heart damage in mice.

• Authors: Kun Liu, Xiu-Mei Ren, Qing-Sheng You, Ming-Ming Gu, Fei Wang, Shuo Wang, Chun-Hui Ma, Wei-Nan Li, Qing Ye
• Journal: BioMed research international (Biomed Res Int) Vol. 2018 Pg. 8503109 ( 2018) ISSN: 2314-6141 [Electronic] United States
• PMID: 30515415 (Publication Type: Journal Article)

Chemical References

• Drugs, Chinese Herbal
• NF-kappa B
• danggui buxue decoction
• Cyclophosphamide
• L-Lactate Dehydrogenase
• Aspartate Aminotransferases
• Alanine Transaminase
• Creatine Kinase

Topics

• Alanine Transaminase (blood)
• Animals
• Aspartate Aminotransferases (blood)
• Blood Platelets (metabolism)
• Creatine Kinase (blood)
• Cyclophosphamide (toxicity)
• Drugs, Chinese Herbal (administration & dosage)
• Heart (drug effects, physiopathology)
• Heart Injuries (blood, chemically induced, drug therapy, physiopathology)
• Humans
• L-Lactate Dehydrogenase (blood)
• Leukocytes (metabolism)
• Mice
• NF-kappa B (genetics)
• Signal Transduction (drug effects)