IL-17 and IL-17-producing cells and liver diseases, with focus on autoimmune liver diseases.

Abstract

The pro-inflammatory cytokine interleukin(IL)-17 and IL-17-producing cells are important players in the pathogenesis of many autoimmune / inflammatory diseases. More recently, they have been associated with liver diseases. This review first describes the general knowledge on IL-17 and IL-17 producing cells. The second part describes the in vitro and in vivo effects of IL-17 on liver cells and the contribution of IL-17 producing cells to liver diseases. IL-17 induces immune cell infiltration and liver damage driving to hepatic inflammation and fibrosis and contributes to autoimmune liver diseases. The circulating levels of IL-17 and the frequency of IL-17-producing cells are elevated in a variety of acute and chronic liver diseases. The last part focuses on the effects of IL-17 deletion or neutralization in various murine models. Some of these observed beneficial effects suggest that targeting the IL-17 axis could be a new therapeutic strategy to prevent chronicity and progression of various liver diseases.

• Authors: Audrey Beringer, Pierre Miossec
• Journal: Autoimmunity reviews (Autoimmun Rev) Vol. 17 Issue 12 Pg. 1176-1185 (Dec 2018) ISSN: 1873-0183 [Electronic] Netherlands
• PMID: 30321671 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2018 Elsevier B.V. All rights reserved.

Chemical References

• Interleukin-17

Topics

• Animals
• Autoimmune Diseases (immunology, metabolism, pathology)
• Humans
• Interleukin-17 (immunology, metabolism)
• Liver Diseases (immunology, metabolism, pathology)