Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats.

Abstract

As a chronic disease, osteoarthritis (OA) leads to the degradation of both cartilage and subchondral bone, its development being mediated by proinflammatory cytokines like interleukin-1β. In the present study, the anti-inflammatory effect of specnuezhenide (SPN) in OA and its underlying mechanism were studied in vitro and in vivo. The results showed that SPN decreases the expression of cartilage matrix-degrading enzymes and the activation of NF-κB and wnt/β-catenin signaling, and increases chondrocyte-specific gene expression in IL-1β-induced inflammation in chondrocytes. Furthermore, SPN treatment prevents the degeneration of both cartilage and subchondral bone in a rat model of OA. To the best of our knowledge, this study is the first to report that SPN decreases interleukin-1β-induced inflammation in rat chondrocytes by inhibiting the activation of the NF-κB and wnt/β-catenin pathways, and, thus, has therapeutic potential in the treatment of OA.

• Authors: Chiyuan Ma, Xiaopeng Zhou, Kai Xu, Linyan Wang, Yute Yang, Wei Wang, An Liu, Jisheng Ran, Shigui Yan, Haobo Wu, Lidong Wu
• Journal: Frontiers in pharmacology (Front Pharmacol) Vol. 9 Pg. 700 ( 2018) ISSN: 1663-9812 [Print] Switzerland
• PMID: 30050432 (Publication Type: Journal Article)