Abstract | OBJECTIVE: METHODS: RESULTS: Cognitive function was impaired in the autologous blood injection group compared with the control group. In the blood injection group, Aβ accumulation was observed, with a co-located correlation between iron storage protein ferritin and Aβ. Beta-site amyloid precursor protein cleaving enzyme-1 (BACE1) activity was elevated. Microgliosis and astrogliosis were observed in hippocampal CA1, CA2, CA3, and dentate gyrus areas, with elevated proinflammatory cytokines tumor necrosis factor-α and interleukin-1. Protein levels of phosphorylated JNK were increased after blood injection. CONCLUSIONS:
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Authors | Conglin Jiang, Xiang Zou, Renqing Zhu, Yimin Shi, Zehan Wu, Fan Zhao, Liang Chen |
Journal | Journal of neurosurgery
(J Neurosurg)
Vol. 131
Issue 1
Pg. 54-63
(Jul 20 2018)
ISSN: 1933-0693 [Electronic] United States |
PMID | 30028260
(Publication Type: Journal Article)
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