Current and emerging diagnosis tools and therapeutics for giant cell arteritis.

Abstract

INTRODUCTION:

Giant cell arteritis (GCA) is the most common large-vessel vasculitis in individuals older than 50 years from Western countries. The goal of the treatment is to achieve improvement of symptoms and clinical remission as well as decrease the risk of severe vascular complications. Areas covered: The review summarizes the main epidemiological and clinical features of GCA and discusses in depth both the classic and the new therapies used in the management of GCA. Expert commentary: Prednisone/prednisolone of 40-60 mg/day is the mainstay in GCA therapy. It yields improvement of clinical features and reduces the risk of permanent visual loss in patients with GCA. Other drugs are used in patients who experience relapses (flares of the disease) or side effects related to glucocorticoids. Methotrexate is the most common conventional immunosuppressive drug used as a glucocorticoid sparing agent. Among the new biologic agents, the most frequently used is the recombinant humanized anti-IL-6 receptor antibody, which is effective to improve clinical symptoms, decrease the cumulative prednisone dose, and reduce the frequency of relapses in these patients. Antitumor necrosis factor-α therapy is not useful in GCA. Experience with other biologic agents, such as abatacept or ustekinumab, looks promising but it is still scarce.

• Authors: Miguel A González-Gay, Trinitario Pina, Diana Prieto-Peña, Mónica Calderon-Goercke, Ricardo Blanco, Santos Castañeda
• Journal: Expert review of clinical immunology (Expert Rev Clin Immunol) Vol. 14 Issue 7 Pg. 593-605 (07 2018) ISSN: 1744-8409 [Electronic] England
• PMID: 29877748 (Publication Type: Journal Article, Review)

Chemical References

• Antibodies, Monoclonal, Humanized
• Glucocorticoids
• Receptors, Interleukin-6
• tocilizumab
• Methotrexate

Topics

• Aged
• Aged, 80 and over
• Animals
• Antibodies, Monoclonal, Humanized (therapeutic use)
• Biological Therapy
• Giant Cell Arteritis (diagnosis, drug therapy)
• Glucocorticoids (therapeutic use)
• Humans
• Methotrexate (therapeutic use)
• Middle Aged
• Receptors, Interleukin-6 (immunology)