A Guide to IL-1 family cytokines in adjuvanticity.

Abstract

Growing awareness of the multiplicity of roles for the IL-1 family in immune regulation has prompted research exploring these cytokines in the context of vaccine-induced immunity. While tightly regulated, cytokines of the IL-1 family are normally released in response to cellular stress and in combination with other danger-/damage-associated molecular patterns (DAMPs), triggering potent local and systemic immune responses. In the context of infection or autoimmunity, engagement of IL-1 family receptors links robust innate responses to adaptive immunity. Clinical and experimental evidence has revealed that many vaccine adjuvants induce the release of one or multiple IL-1 family cytokines. The coordinated release of IL-1 family members in response to adjuvant-induced damage or cell death may be a determining factor in the transition from local inflammation to the induction of an adaptive response. Here, we analyse the effects of IL-1 family cytokines on innate and adaptive immunity with a particular emphasis on activation of antigen-presenting cells and induction of T cell-mediated immunity, and we address in detail the contribution of these cytokines to the modes of action of vaccine adjuvants including those currently approved for human use.

• Authors: Natalia Muñoz-Wolf, Ed C Lavelle
• Journal: The FEBS journal (FEBS J) Vol. 285 Issue 13 Pg. 2377-2401 (07 2018) ISSN: 1742-4658 [Electronic] England
• PMID: 29656546 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2018 Federation of European Biochemical Societies.

Chemical References

• Adjuvants, Immunologic
• Cytokines
• Interleukin-1

Topics

• Adaptive Immunity (drug effects, immunology)
• Adjuvants, Immunologic (pharmacology)
• Animals
• Antigen-Presenting Cells (drug effects, immunology, metabolism)
• Cytokines (immunology, metabolism)
• Humans
• Immunity, Innate (drug effects, immunology)
• Interleukin-1 (immunology, metabolism)
• Stress, Physiological (drug effects, immunology)
• T-Lymphocytes (drug effects, immunology, metabolism)