Mixed and inhomogeneous expression profile of Th1/Th2 related cytokines detected by cytometric bead array in the saliva of patients with oral lichen planus.

Abstract

OBJECTIVE:

The aim of this study was to measure T helper (Th) 1/Th2-related cytokine expression in saliva from patients with oral lichen planus (OLP), compared with healthy controls (HC group) and controls with recurrent aphthous ulcers (RAU group).

STUDY DESIGN:

Saliva was collected from 41 patients with OLP, 14 HCs, and 14 controls with RAU for Th1/Th2-related cytokines analysis with cytometric bead array. Disease activity in OLP was recorded by reticulation/keratosis, erythema, and ulceration scores.

RESULTS:

Interleukin (IL)-6, IL-10, interferon-γ (IFN-γ), and IFN-γ/IL-4 in saliva were significantly higher in the OLP group than in the HC group. A positive and significant correlation among IL-6, IL-10, and reticulation/keratosis, erythema, and ulceration scores in the OLP group was revealed. Significantly increased IL-4, IL-5, IL-6, IL-10, tumor necrosis factor-α and IFN-γ/IL-4 were found in the RAU group.

CONCLUSIONS:

Salivary cytokine profiles analyzed by cytometric bead array may provide a convenient research approach to OLP. Data indicated complicated Th1/Th2-related cytokine profile changes, rather than simple dominance model, in OLP. IL-10 and especially IL-6 may provide a surrogate endpoint for monitoring OLP.

• Authors: Wei Wei, Qianqian Sun, Yiwen Deng, Yufeng Wang, Guanhuan Du, Chencheng Song, Chenxi Li, Mengxue Zhu, Guangjie Chen, Guoyao Tang
• Journal: Oral surgery, oral medicine, oral pathology and oral radiology (Oral Surg Oral Med Oral Pathol Oral Radiol) Vol. 126 Issue 2 Pg. 142-151 (08 2018) ISSN: 2212-4411 [Electronic] United States
• PMID: 29627199 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier Inc. All rights reserved.

Chemical References

• Cytokines
• Interleukin-6
• Interleukin-10

Topics

• Cytokines (metabolism)
• Female
• Flow Cytometry (methods)
• Humans
• Interleukin-10 (metabolism)
• Interleukin-6 (metabolism)
• Lichen Planus, Oral (metabolism)
• Male
• Middle Aged
• Saliva (chemistry)