Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with Inflammation in Type 2 Diabetes Mellitus.

Abstract	Brain-derived neurotrophic factor (BDNF) is a neurotrophin, which plays an important role in the central nervous system, and systemic or peripheral inflammatory conditions, such as acute coronary syndrome and type 2 diabetes mellitus (T2DM). BDNF is also expressed in several nonneuronal tissues, and platelets are the major source of peripheral BDNF. Here, we reviewed the potential role of BDNF in platelet reactivity in T2DM and its association with selected inflammatory and platelet activation mediators. Besides that, we focused on adipocytokines such as leptin, resistin, and adiponectin which are considered to take part in inflammation and both lipid and glucose metabolism in diabetic patients as previous studies showed the relation between adipocytokines and BDNF. We also reviewed the evidences of the antidiabetic effect of BDNF and the association with circulating inflammatory cytokines in T2DM.
Authors	Ceren Eyileten, Agnieszka Kaplon-Cieslicka, Dagmara Mirowska-Guzel, Lukasz Malek, Marek Postula
Journal	Journal of diabetes research (J Diabetes Res) Vol. 2017 Pg. 2823671 ( 2017) ISSN: 2314-6753 [Electronic] England
PMID	29062839 (Publication Type: Journal Article, Review)
Chemical References	Adipokines Blood Glucose Brain-Derived Neurotrophic Factor Cytokines Hypoglycemic Agents Inflammation Mediators BDNF protein, human Receptor, trkB
Topics	Adipokines (blood) Animals Blood Glucose (drug effects, metabolism) Blood Platelets (drug effects, metabolism) Brain (drug effects, metabolism, physiopathology) Brain-Derived Neurotrophic Factor (adverse effects, blood, therapeutic use) Cytokines (blood) Diabetes Mellitus, Type 2 (blood, drug therapy, epidemiology, physiopathology) Humans Hypoglycemic Agents (adverse effects, therapeutic use) Inflammation (blood, epidemiology, physiopathology) Inflammation Mediators (blood) Platelet Activation (drug effects) Receptor, trkB (agonists, metabolism) Signal Transduction (drug effects) Treatment Outcome

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