A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow.

Abstract

A 48-year-old man was admitted due to marked leukocytosis. Bone marrow examinations resulted in a diagnosis of Philadelphia (Ph) chromosome-positive chronic myeloid leukemia. One month later, massive muscle and bone invasion by leukemic cells was detected. After induction chemotherapy, he complained of a headache and visual loss, which was caused by a leukemic infiltration in the central nervous system. After temporary remission in response to chemotherapy, the disease relapsed in the form of an intracranial tumor. The unusual t(14;22)(q24;q11.2) translocation of the Ph-chromosome and the significant increase in monocytes observed might have contributed to the unique and aggressive clinical course.

• Authors: Morihiro Inoue, Masao Hagihara, Tomoyuki Uchida, Jian Hua, Takeshi Nakajima, Shogo Tajima, Yasunori Ota
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 56 Issue 24 Pg. 3341-3346 (Dec 15 2017) ISSN: 1349-7235 [Electronic] Japan
• PMID: 29021476 (Publication Type: Case Reports, Journal Article)

Topics

• Blast Crisis (pathology)
• Bone Marrow Neoplasms (secondary)
• Central Nervous System Neoplasms (secondary)
• Humans
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive (drug therapy, genetics, pathology)
• Male
• Middle Aged
• Monocytes (pathology)
• Philadelphia Chromosome
• Translocation, Genetic