Efficacy of Cefquinome against Escherichia coli Environmental Mastitis Assessed by Pharmacokinetic and Pharmacodynamic Integration in Lactating Mouse Model.

Abstract

This work investigates the pharmacodynamic effectiveness of cefquinome against environmental Escherichia coli mastitis infection, following an intramammary administration. We established the pharmacokinetic and pharmacodynamic (PK/PD) model in lactating mice. The PK/PD parameters were identified to achieve an antibacterial efficacy as indicated by PD activity, cytokine expression and PK/PD simulation. From our findings, given an 200 μg/gland dose once daily can achieve a considerable therapeutic effectiveness in experimental circumstance.

• Authors: Yang Yu, Jin-Tao Fang, Jian Sun, Mei Zheng, Qing Zhang, Jie-Shun He, Xiao-Ping Liao, Ya-Hong Liu
• Journal: Frontiers in microbiology (Front Microbiol) Vol. 8 Pg. 1445 ( 2017) ISSN: 1664-302X [Print] Switzerland
• PMID: 28824576 (Publication Type: Journal Article)