Bone-targeted cabazitaxel nanoparticles for metastatic prostate cancer skeletal lesions and pain.

Abstract

AIM:

The aim of this study was to develop a novel cabazitaxel bone targeted nanoparticle (NP) system for improved drug delivery to the bone microenvironment.

MATERIALS & METHODS:

Nanoparticles were developed using poly(D,L-lactic-co-glycolic acid) and cabazitaxel as the core with amino-bisphosphonate surface conjugation. Optimization of nanoparticle physiochemical properties, in vitro evaluation in prostate cancer cell lines and in vivo testing in an intraosseous model of metastatic prostate cancer was performed.

RESULTS:

This bone targeted cabazitaxel nanocarrier system showed significant reduction in tumor burden, while at the same time maintaining bone structure integrity and reducing pain in the mouse tumor limb.

CONCLUSION:

This bone microenvironment targeted nanoparticle system and clinically relevant approach of evaluation represents a promising advancement for treating bone metastatic cancer.

• Authors: Andrew S Gdowski, Amalendu Ranjan, Marjana R Sarker, Jamboor K Vishwanatha
• Journal: Nanomedicine (London, England) (Nanomedicine (Lond)) Vol. 12 Issue 17 Pg. 2083-2095 (Sep 2017) ISSN: 1748-6963 [Electronic] England
• PMID: 28805551 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Diphosphonates
• Drug Carriers
• Taxoids
• Polylactic Acid-Polyglycolic Acid Copolymer
• Polyglycolic Acid
• Lactic Acid
• cabazitaxel

Topics

• Animals
• Antineoplastic Agents (chemistry, pharmacology)
• Bone Neoplasms (drug therapy, secondary)
• Bone and Bones (drug effects)
• Cell Line, Tumor
• Cell Survival
• Diphosphonates (chemistry, pharmacology)
• Drug Carriers (chemistry)
• Drug Liberation
• Humans
• Lactic Acid (chemistry)
• Male
• Mice
• Mice, Nude
• Nanoparticles (chemistry)
• Pain (drug therapy)
• Particle Size
• Polyglycolic Acid (chemistry)
• Polylactic Acid-Polyglycolic Acid Copolymer
• Prostatic Neoplasms (drug therapy, pathology)
• Surface Properties
• Taxoids (chemistry, pharmacology)
• Xenograft Model Antitumor Assays