Polylactic Acid-Polyglycolic Acid Copolymer

A co-polymer that consists of varying ratios of polylactic acid and polyglycolic acid. It is used as a matrix for drug delivery and for BONE REGENERATION.

Also Known As:

LactoSorb; PL-PG Copolymer; PLG Polymer; PLGA Compound; Poly (D,L-lactic-co-glycolic Acid); Poly (Lactic-co-glycolic Acid) -; Poly(D,L-lactide-co-glycolide); Poly(DL-lactide-co-glycolic Acid); Poly(Glycolide-co-lactide); Poly(L-lactide)-co-glycolide; Poly(Lactic-co-glycolic Acid); Poly-L-lactic-polyglycolic Acid; Polylactic-co-glycolic Acid Copolymer; RG 502; Acid, PLGA; Acids, PLGA; Copolymer, PL-PG; Copolymer, Polylactic-co-glycolic Acid; Copolymers, PL-PG; Copolymers, Polylactic-co-glycolic Acid; PL PG Copolymer; PL-PG Copolymers; PLG Polymers; PLGA Acids; PLGA Compounds; Poly L lactic polyglycolic Acid; Poly-L-lactic-polyglycolic Acids; Polylactic Acid Polyglycolic Acid Copolymer; Polylactic co glycolic Acid Copolymer; Polylactic-co-glycolic Acid Copolymers; Polymer, PLG; Polymers, PLG; PLGA Acid

Networked: 1200 relevant articles (84 outcomes, 287 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liu, Shih-Jung: 13 articles (06/2022 - 01/2014)
2.	Wang, Yan: 9 articles (03/2022 - 11/2012)
3.	Zhang, Yu: 9 articles (12/2021 - 01/2013)
4.	Wang, Zhigang: 9 articles (03/2021 - 08/2012)
5.	Li, Pan: 8 articles (03/2021 - 08/2012)
6.	Burgess, Diane J: 8 articles (01/2021 - 12/2004)
7.	Yang, Hong: 8 articles (01/2020 - 04/2014)
8.	Kim, Dong Woon: 7 articles (01/2022 - 01/2019)
9.	Cho, Hyun-Jong: 7 articles (09/2021 - 10/2014)
10.	Nguyen, Kytai T: 7 articles (01/2021 - 04/2012)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "This study explores poly(lactic-co-glycolic acid) (PLGA) nanoparticles to enhance the delivery of oxidized tumor lysate to dendritic cells. " 07/21/2020 - "In this study, a poly(lactic-co-glycolic acid) nanoparticle (NP)-based drug delivery system capable of encapsulating the chemodrug SN38 and enhancing drug accumulation in metastatic tumors was developed for the treatment of pcCRC. " 03/01/2015 - "Previous studies showed that the encapsulation of 9-NC in poly (lactic-co-glycolic acid, PLGA) nanoparticles increased the cytotoxic effect of the drug on different cancer cell lines. " 08/25/2014 - "As a result, SN38 loaded poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) was developed in current study to solve its poor water solubility problem while maintaining its cytotoxicity against cancer cells. " 08/01/2023 - "Radiolabeled poly(lactic-co-glycolic) acid nanocarrier (NINP) was developed for NIS targeted delivery of I-131 to MDA-MB-231 cells to overcome I-131 low uptake in cancer cells and rapid clearance. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "This study tested primary patient breast cancer cells in vitro with traditional free DTX in comparison with polymeric nanocarriers based on poly lactic co-glycolic acid (PLGA) NPs. " 01/01/2016 - "To enhance the solubility and improve the bioavailability of EVO, a delivery system based on poly (lactic-co-glycolic acid) (PLGA) nanoparticles loaded with EVO (EVO-PLGA NPs) for treating breast cancer was prepared in this study. " 10/15/2022 - "Thus, to increase the therapeutic effectiveness of AA in the treatment of breast cancer, AA-loaded poly lactic-co-glycolic acid (PLGA) NPs (AA-PLGA NPs) have been formulated. " 09/01/2017 - "A novel fluorescent poly(lactic-co-glycolic) acid (PLGA) nanoparticle conjugated with anti-EGFR was intravenously injected to specifically target the breast cancer cells. " 11/21/2023 - "Poly (lactic-co-glycolic acid) microspheres (150-200 mm) with tailorable pore size and surface topography are fabricated and used as carriers to respectively lade with breast tumor-associated cells. "
3.	Infections 10/01/2020 - "Poly lactic-co-glycolic acid (PLGA)-based nanoparticle delivery systems have been intensively investigated to combat the bacterial biofilms-associated infections. " 11/14/2007 - "A genetically engineered prime-boost vaccination strategy for oculonasal delivery with poly(D,L-lactic-co-glycolic acid) microparticles against infection of turkeys with avian Metapneumovirus." 09/01/1998 - "For those patients reviewed, the following information is included: age, sex, diagnosis, surgical procedures, number and size of LactoSorb plates and screws used in each patient, operative difficulty of the screws and the heat pack, and postoperative complications, including wound healing, palpability, and infection. " 05/01/2021 - "Poly (D, L-lactide-co-glycolide) delivery system improve the protective efficacy of recombinant antigen TA4 against Eimeria tenella infection." 10/15/2014 - "Poly D,L-lactide-co-glycolide (PLGA) nanoparticle-encapsulated honeybee (Apis melifera) venom promotes clearance of Salmonella enterica serovar Typhimurium infection in experimentally challenged pigs through the up-regulation of T helper type 1 specific immune responses."
4.	Wounds and Injuries (Trauma) 05/01/2014 - "In this study, various concentrations of EGCG were added to the electrospun membranes composed of poly (lactic-co-glycolic acid) (PLGA), and its healing effects on full-thickness wounds created in nude mice were investigated. " 01/01/2021 - "Poly lactic-co-glycolic acid (PLGA) has been widely investigated for various biomedical applications, such as craniofacial bone regeneration, wound dressing and tissue engineering. " 01/01/2016 - "A bio-artificial poly([D,L]-lactide-co-glycolide) drug-eluting nanofibrous periosteum for segmental long bone open fractures with significant periosteal stripping injuries." 05/01/2000 - "Furthermore, LactoSorb was used in 10 patients with craniosynostosis or craniofacial trauma. " 01/01/2022 - "To examine the poly (lactic-co-glycolic acid) and sodium alginate (SA) scaffolds produced by 3D printing technology, access the healing morphology of bones following PLGA/SA implantation within rat cartilage, and examine osteogenesis-related factors in rat serum to determine the efficacy of PLGA/SA scaffolds in healing animal cartilage injuries. "
5.	Prostatic Neoplasms (Prostate Cancer) 12/01/2015 - "This involved the development of a BLT-loaded poly(D,L-lactide-co-glycolide) PLGA (PLGA-BLT) nanoparticulate system in an attempt to improve the therapeutic efficacy of BLT in prostate cancer and to mitigate its toxicity. " 10/01/2014 - "The objective of this study was to evaluate therapeutic potential of novel poly(lactic-co-glycolic acid)- CUR nanoparticles (PLGA-CUR NPs) for prostate cancer treatment. " 12/01/2016 - "In the present study, a highly stable luteinizing-hormone-releasing hormone (LHRH)-conjugated PEGylated poly(lactic-co-glycolic acid) (PLGA) nanoparticles were developed for the successful treatment of prostate cancers. " 09/29/2019 - "Impregnation of Curcumin into a Biodegradable (Poly-lactic-co-glycolic acid, PLGA) Support, to Transfer Its Well Known In Vitro Effect to an In Vivo Prostate Cancer Model." 12/01/2016 - "Highly Stable PEGylated Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for the Effective Delivery of Docetaxel in Prostate Cancers."

Related Drugs and Biologics

1.	Ethylene Glycol (Monoethylene Glycol)
2.	Small Interfering RNA (siRNA)
3.	Curcumin
4.	Peptides (Polypeptides)
5.	Antigens
6.	Emulsions
7.	Doxorubicin (Adriamycin)
8.	Polymers
9.	Paclitaxel (Taxol)
10.	Polyethyleneimine

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Lasers (Laser)
3.	Therapeutics
4.	Drug Therapy (Chemotherapy)
5.	Microbubbles