Abstract | BACKGROUND:
Allergic contact dermatitis (ACD), which is accelerated by interferon (IFN)-γ and suppressed by interleukin (IL)-10 as regulators, is generally self-limited after removal of the contact allergen. Adipose tissue-derived multipotent mesenchymal stem cells (ASCs) potentially exert immunomodulatory effects. Considering that subcutaneous adipose tissue is located close to the site of ACD and includes mesenchymal stem cells (MSCs), the MSCs in adipose tissue could contribute to the self-limiting course of ACD. OBJECTIVE: The aims of the present study were to elucidate the effects of MSCs in adipose tissue on ACD and to examine any cytokine-mediated mechanisms involved. METHODS: RESULTS: Histology showed that CHS was self-limited and ear thickness was suppressed by ASCs in a dose-dependent manner. IFN-γ expression in the elicited skin site and regional lymph nodes was significantly lower in ASC-treated mice than in control mice. IL-10 expression did not differ between treated and control mice. The suppressive effects of ASCs on CHS response did not differ between IL-10 knock-out C57BL/6 mice and wild-type mice. CONCLUSION: The present findings suggest that MSCs in adipose tissue may contribute to the self-limiting course of ACD through decreased expression of IFN-γ, but not through increased expression of IL-10.
|
Authors | Sota Kikuchi, Koichi Yanaba, Yoshimasa Nobeyama, Shigeharu Yabe, Masahiro Kiso, Hidehisa Saeki, Yayoi Tada, Hidemi Nakagawa, Hitoshi Okochi |
Journal | Annals of dermatology
(Ann Dermatol)
Vol. 29
Issue 4
Pg. 391-399
(Aug 2017)
ISSN: 1013-9087 [Print] Korea (South) |
PMID | 28761285
(Publication Type: Journal Article)
|