Surgical suture braided with a diclofenac-loaded strand of poly(lactic-co-glycolic acid) for local, sustained pain mitigation.

Abstract

In this work, we propose a surgical suture that can sustainably release diclofenac (DF) for the local pain relief of surgical wounds. We separately fabricated a DF-loaded strand composed of a biodegradable polymer, poly(lactic-co-glycolic acid) (PLGA), which was then braided with a surgical suture already in clinical use, i.e., VICRYL™. In this way, the drug-delivery suture presented herein could release DF in a sustained manner for 10days while maintaining the mechanical strength needed for wound closure. According to the in vivo results of an induced-pain animal model, the drug-delivery suture mitigated pain throughout the period of persistent pain. The histological analysis of tissue around the sutures showed that the drug-delivery suture exhibited biocompatibility comparable to that of the VICRYL™ suture in clinical use.

• Authors: Beom Kang Huh, Byung Hwi Kim, Se-Na Kim, Chun Gwon Park, Seung Ho Lee, Ka Ryeong Kim, Chan Yeong Heo, Young Bin Choy
• Journal: Materials science & engineering. C, Materials for biological applications (Mater Sci Eng C Mater Biol Appl) Vol. 79 Pg. 209-215 (Oct 01 2017) ISSN: 1873-0191 [Electronic] Netherlands
• PMID: 28629009 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier B.V. All rights reserved.

Chemical References

• Diclofenac
• Polylactic Acid-Polyglycolic Acid Copolymer
• Polyglycolic Acid
• Lactic Acid

Topics

• Animals
• Diclofenac (chemistry)
• Lactic Acid
• Pain
• Polyglycolic Acid
• Polylactic Acid-Polyglycolic Acid Copolymer
• Sutures