Abstract | BACKGROUND: This study investigated the protective effect of aplysin on the liver and its influence on inflammation and the gut microbiota in rats with ethanol-induced liver injury. METHODS: Male Sprague-Dawley rats were randomly assigned to an alcohol-containing liquid diet, control liquid diet or treatment with aplysin for 8 weeks. Hepatic and intestinal histopathological analysis was performed, and cytokine levels and the intestinal mucosal barrier were assessed. Enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC-PCR) and 16S rDNA high-throughput sequencing were performed to provide an overview of the gut microbiota composition. RESULTS: CONCLUSIONS: These results suggest that aplysin exerts a protective effect on ethanol-induced hepatic injury in rats by normalizing fecal microbiota composition and repairing intestinal barrier function.
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Authors | Meilan Xue, Ying Liu, Rui Lyu, Na Ge, Man Liu, Yan Ma, Hui Liang |
Journal | PloS one
(PLoS One)
Vol. 12
Issue 6
Pg. e0178684
( 2017)
ISSN: 1932-6203 [Electronic] United States |
PMID | 28622357
(Publication Type: Journal Article)
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Chemical References |
- Cytokines
- DNA, Bacterial
- DNA, Ribosomal
- Hydrocarbons, Brominated
- RNA, Ribosomal, 16S
- Sesquiterpenes
- Ethanol
- aplysin
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Topics |
- Animals
- Chemical and Drug Induced Liver Injury
(metabolism, microbiology)
- Cytokines
(blood)
- DNA, Bacterial
(genetics)
- DNA, Ribosomal
(genetics)
- Enterobacteriaceae
(genetics, metabolism)
- Ethanol
(adverse effects, pharmacology)
- Gastrointestinal Microbiome
(drug effects, genetics)
- Hydrocarbons, Brominated
(pharmacology)
- Liver
(metabolism, pathology)
- Male
- RNA, Ribosomal, 16S
(genetics)
- Rats
- Rats, Sprague-Dawley
- Sesquiterpenes
(pharmacology)
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