Examining HIV Viral Load in a Matched Cohort of HIV Positive Individuals With and Without Psoriasis.

Abstract

<p>BACKGROUND: HIV-associated psoriasis is well-documented. Genetic, cellular, and cytokine profiles have been used as evidence to suggest psoriasis activates antiviral pathways. There has been a lack of epidemiologic evidence investigating whether psoriasis patients have lower HIV viral counts compared to non-psoriasis patients.</p> <p>OBJECTIVE: Compare the viral load set point of HIV positive patients with and without psoriasis.</p> <p>METHODS: A retrospective matched cohort study of HIV positive patients with and without psoriasis using the Kaiser Permanente Southern California Health Plan database.</p> <p>RESULTS: We identified 101 HIV-positive psoriasis cases; 19 met inclusion criteria and were matched with 3-5 control patients; 94 total patients were analyzed. The mean age was 41.4 (12.07) years and 83% were male. Overall, the median log of the viral load of cases was slightly higher than controls (4.3 vs 4.2; P less than 0.01).</p> <p>CONCLUSIONS: The serum viral load set point of patients with HIV and psoriasis was slightly higher than the viral load set point of HIV patients without psoriasis.</p> <p><em>J Drugs Dermatol. 2017;16(4):372-377.</em></p>.

• Authors: Jashin J Wu, Kathleen E Gilbert, Michael Batech, Iviensan F Manalo, William J Towner, Rui André Saraiva Raposo, Douglas F Nixon, Wilson Liao
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 16 Issue 4 Pg. 372-377 (Apr 01 2017) ISSN: 1545-9616 [Print] United States
• PMID: 28403272 (Publication Type: Comparative Study, Journal Article)

Topics

• Adult
• Aged
• California
• Case-Control Studies
• Female
• HIV (isolation & purification)
• HIV Infections (blood, complications, virology)
• Humans
• Male
• Middle Aged
• Psoriasis (blood, complications)
• Retrospective Studies
• Viral Load
• Young Adult