Abstract | BACKGROUND: METHODS: Aged mice underwent sham surgery or 60min of hepatic ischemia reperfusion, vehicle or ribonuclease, which were administered subcutaneously. The primary observation endpoint was the Morris water maze; following 24h, 3days, and 7days of reperfusion, the levels of serum and hippocampus proinflammatory cytokines were measured to reveal the underlying mechanism. RESULTS: A probe test was conducted on day 3 and a reversal probe test was conducted on day 7 after surgery; the results demonstrated a reduction in cognitive function after liver ischemia reperfusion and that ribonuclease treatment attenuated cognitive impairment. The levels of serum and hippocampus proinflammatory cytokines (interleukin-6 and interleukin-1β) and extracellular ribonucleic acid were significantly increased at 24h after reperfusion, but ribonuclease treatment markedly reduced the proinflammatory cytokine increase. CONCLUSION:
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Authors | Gang Ma, Chan Chen, Haixia Jiang, Yanhua Qiu, Yansong Li, Xiaoqiang Li, Xiyang Zhang, Jin Liu, Tao Zhu |
Journal | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
(Biomed Pharmacother)
Vol. 90
Pg. 62-68
(Jun 2017)
ISSN: 1950-6007 [Electronic] France |
PMID | 28343072
(Publication Type: Journal Article)
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Copyright | Copyright © 2017 Elsevier Masson SAS. All rights reserved. |
Chemical References |
- Cytokines
- Interleukin-1beta
- Interleukin-6
- Ribonucleases
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Topics |
- Animals
- Cognitive Dysfunction
(drug therapy, etiology, metabolism)
- Cytokines
(metabolism)
- Disease Models, Animal
- Hippocampus
(drug effects, metabolism)
- Inflammation
(drug therapy, metabolism)
- Interleukin-1beta
(metabolism)
- Interleukin-6
(metabolism)
- Liver
(drug effects, metabolism)
- Liver Diseases
(drug therapy, metabolism)
- Male
- Mice
- Mice, Inbred C57BL
- Reperfusion Injury
(complications, metabolism)
- Ribonucleases
(pharmacology)
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