Abstract | AIM: METHODS: RESULTS:
Cytokine levels in the CSF did not differ between the two subgroups. Macrophage inflammatory protein-1β levels in the CSF significantly correlated with PiB retention only in the PiB-positive subgroup, whereas stem cell growth factor-β levels significantly correlated with PiB retention in the PiB-negative subgroup. Furthermore, stem cell growth factor-β levels significantly correlated with total tau and tau phosphorylated at threonine 181 levels in only the PiB-negative subgroup. CONCLUSION: The present findings suggest that macrophage inflammatory protein-1β and stem cell growth factor-β are associated with chronic inflammatory processes accompanied by amyloid deposition or AD pathophysiology. Geriatr Gerontol Int 2017; 17: 1907-1913.
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Authors | Yoshitake Abe, Noriyuki Kimura, Ryuichi Takahashi, Megumi Gotou, Ken Mizukami, Hirotatsu Uchida, Etsuro Matsubara |
Journal | Geriatrics & gerontology international
(Geriatr Gerontol Int)
Vol. 17
Issue 11
Pg. 1907-1913
(Nov 2017)
ISSN: 1447-0594 [Electronic] Japan |
PMID | 28261965
(Publication Type: Journal Article)
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Copyright | © 2017 Japan Geriatrics Society. |
Chemical References |
- 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
- Aniline Compounds
- Cytokines
- Thiazoles
|
Topics |
- Aged
- Aniline Compounds
(metabolism)
- Cognitive Dysfunction
(metabolism)
- Cytokines
(cerebrospinal fluid)
- Female
- Humans
- Male
- Thiazoles
(metabolism)
|