Abstract | BACKGROUND/PURPOSE: High-mobility group box-1 ( HMGB1), a proinflammatory cytokine, plays a role in inflammatory disorders. Smoking is a well-established risk factor for periodontal disease. The aim of this study was to compare the levels of HMGB1 in the gingival crevicular fluid from periodontally healthy nonsmokers, chronic periodontitis nonsmokers, and chronic periodontitis smokers. Furthermore, the relationship between levels of HMGB1 and periodontal parameters was examined. METHODS: RESULTS: The median level of HMGB1 was statistically significantly higher in chronic periodontitis nonsmokers (37.5 ng/mL) than in chronic periodontitis smokers (9.5 ng/mL) and periodontally healthy nonsmokers (3.7 ng/mL). There was no significant difference in the levels of HMGB1 between chronic periodontitis smokers and periodontally healthy nonsmokers. Levels of HMGB1 were positively correlated with plaque index, gingival index, probing depth, and clinical attachment level of nonsmokers. However, no significant correlations were found between levels of HMGB1 and all periodontal parameters examined in chronic periodontitis smokers. CONCLUSION:
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Authors | Yi-Chun Lin, Ching-Yi Wu, Lien-Yu Chang, Ching-Chu Chen, Hsuan-Hung Chen, Yu-Lin Lai, Shan-Ling Hung |
Journal | Journal of the Formosan Medical Association = Taiwan yi zhi
(J Formos Med Assoc)
Vol. 116
Issue 12
Pg. 933-939
(Dec 2017)
ISSN: 0929-6646 [Print] Singapore |
PMID | 28209360
(Publication Type: Journal Article)
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Copyright | Copyright © 2017. Published by Elsevier B.V. |
Chemical References |
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Topics |
- Adult
- Case-Control Studies
- Chronic Periodontitis
(metabolism)
- Dental Health Surveys
- Female
- Gingival Crevicular Fluid
(metabolism)
- HMGB1 Protein
(metabolism)
- Humans
- Male
- Middle Aged
- Smoking
(metabolism)
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