Acetaminophen-induced hepatotoxicity: Preventive effect of trans anethole.

Abstract

The hepatotoxicity induced by APAP is caused by the excessive production of N-acetyl-para-benzoquinone imine (NAPQI), which, when reacting with hepatic proteins proved to cause irreversible lesions. Associated with this process, an intense inflammatory process is also evidenced, characterized by the increased cell influx and production/release of inflammatory mediators. Trans anethole, an aromatic compounds has been showed anti-inflammatory efficacy by inhibit the cellular recruitment and synthesis/releases of many proinflammatory mediators such as prostaglandin (PGE2), cytokines (TNF, IL-1) and nitrico oxide (NO). The aim of this study is to investigate the effect of trans anethole on some inflammatory parameters that are involved in hepatotoxicity induced by high doses of acetaminophen. Our results demonstrate that treatment with AN at doses 125 and 250mg/kg once a day for seven days prevented the changes caused by the APAP overdose, showing less intensity in the histological changes (necrosis, size of hepatocyte area and inflammatory infiltration), and corroborating the findings of serum activities of transaminases and phosphatases and the activity of the enzyme myeloperoxidase. In addition, the treatment prevented the up-regulation of proinflammatory mediators such as NO, TNF, IL-1α, MIP-1α and MCP-1 and induced the up-regulation of anti-inflammatory cytokines (IL-4 and IL-10). Thus, our results demonstrate a possible protective effect of trans anethole on the hepatotoxicity induced by APAP.

• Authors: Bruno Ambrósio da Rocha, Alessandra M Versuti Ritter, Franciele Queiroz Ames, Odinei Hess Gonçalves, Fernanda Vitória Leimann, Lívia Bracht, Maria Raquel Marçal Natali, Roberto Kenji Nakamura Cuman, Ciomar Ap Bersani-Amado
• Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (Biomed Pharmacother) Vol. 86 Pg. 213-220 (Feb 2017) ISSN: 1950-6007 [Electronic] France
• PMID: 28006746 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Chemical References

• Allylbenzene Derivatives
• Analgesics, Non-Narcotic
• Anisoles
• Acetaminophen
• anethole

Topics

• Acetaminophen (toxicity)
• Allylbenzene Derivatives
• Analgesics, Non-Narcotic (toxicity)
• Animals
• Anisoles (pharmacology)
• Liver (drug effects, metabolism, pathology)
• Male
• Mice
• Oxidative Stress (drug effects, physiology)