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Methotrexate Use and Monitoring in Patients with Psoriasis: A Consensus Report Based on a Danish Expert Meeting.

Abstract
Methotrexate (MTX) has been used in the treatment of psoriasis and other dermatological diseases for more than 50 years. However, there is limited evidence regarding its effect, dose and monitoring, and a lack of consensus regarding how the drug should be used in daily practice. Although the use of MTX is governed by guidelines, such as the European S3-Guidelines and the National Institute for Health and Care Excellence (NICE) guideline, it is important to discuss and adjust these guidelines to national standards. An expert meeting was held in Denmark at the end of 2014, in order to reach consensus regarding the use of MTX in dermatological practice in Denmark. Participants included dermatologists, hepatologists, paediatricians, clinical biochemists and a rheumatologist. Topics discussed were: liver disease monitoring, teratogenic effects of MTX, risk of cancer, and use of MTX in children. We report here the conclusions of this expert meeting regarding use of MTX in dermatological practice.
AuthorsLine Raaby, Claus Zachariae, Monika Østensen, Lene Heickendorff, Peter Thielsen, Henning Grønbæk, Lone Skov, Nini Kyvsgaard, Jakob T Madsen, Michael Heidenheim, Anne T Funding, Gitte Strauss, Rune Lindberg, Lars Iversen
JournalActa dermato-venereologica (Acta Derm Venereol) Vol. 97 Issue 4 Pg. 426-432 (Apr 06 2017) ISSN: 1651-2057 [Electronic] Sweden
PMID27958611 (Publication Type: Consensus Development Conference, Journal Article, Practice Guideline)
Chemical References
  • Immunosuppressive Agents
  • Methotrexate
Topics
  • Adult
  • Age Factors
  • Chemical and Drug Induced Liver Injury (diagnosis, etiology)
  • Child
  • Consensus
  • Denmark
  • Dermatology (standards)
  • Drug Dosage Calculations
  • Female
  • Humans
  • Immunosuppressive Agents (administration & dosage, adverse effects)
  • Liver Function Tests
  • Male
  • Methotrexate (administration & dosage, adverse effects)
  • Neoplasms (chemically induced, diagnosis)
  • Patient Safety
  • Pregnancy
  • Pregnancy Complications (chemically induced, diagnosis)
  • Psoriasis (diagnosis, drug therapy, immunology)
  • Risk Assessment
  • Risk Factors
  • Time Factors
  • Treatment Outcome

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