Polymorphisms in cytokine genes influence cognitive and functional performance in a population aged 75 years and above.

Abstract

OBJECTIVE:

To investigate the frequency of the cytokine single nucleotide polymorphisms (SNPs) tumor necrosis factor (TNF)-α -308G > A, tumor growth factor (TGF)-β1 codon +10C > T, TGF-β1 codon +25G > C, interleukin (IL)-10 -1082A > G, IL-10 -819C > T, IL-10 -592C > A, IL-6 -174G > C, and IFN-γ +874T > A in a sample of healthy and cognitively impaired elderlies and to verify the probable association between these SNPs and cognitive and functional performance of subjects aged 75 years and above.

METHODS:

259 Brazilian subjects were included, comprising 81 with cognitive impairment no dementia (CIND) and 54 demented seniors (together made up the cognitively impaired group, CI) and 124 age-matched and gender-matched cognitively healthy controls (CHS). The genotyping was performed by multiplex polymerase chain reaction. The cognitive performance was evaluated by Mini-Mental State Examination Brief Cognitive Screening Battery. The functional performance was accessed by Functional Activities Questionnaire.

RESULTS:

The CClower genotype of TGF-β1 codon +25G > C was frequent in both patient groups. The TThigher genotype of INF-γ +874T > A was less frequent in the dementia group. IL-10 haplotypes of lower expression were more frequent among CIND and demented patients. In CI, individuals with genetic variants that produce higher expression of TGF-β1, INF-γ, and IL-10 showed better normalized cognitive performance. Additionally, the Alower allele of INF-γ +874T > A was related to worse functional performance in CI, while the Alower allele of TNF-α -308G > A was associated with better cognitive and functional scores in the CIND group.

CONCLUSIONS:

Our findings suggest a potential role for certain cytokine SNPs in the development of CIND and dementia, which may influence the functional and cognitive performance of these patients. Copyright © 2016 John Wiley & Sons, Ltd.

• Authors: Vanessa G Fraga, Henrique C Guimarães, Antônio L Teixeira, Maira T Barbosa, Maria G Carvalho, Paulo Caramelli, Karina B Gomes
• Journal: International journal of geriatric psychiatry (Int J Geriatr Psychiatry) Vol. 32 Issue 12 Pg. 1401-1410 (12 2017) ISSN: 1099-1166 [Electronic] England
• PMID: 27891653 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 John Wiley & Sons, Ltd.

Chemical References

• Cytokines
• IL10 protein, human
• Interleukin-6
• Transforming Growth Factor beta1
• Tumor Necrosis Factor-alpha
• Interleukin-10
• Interferon-gamma

Topics

• Aged
• Aged, 80 and over
• Alleles
• Brazil
• Case-Control Studies
• Cognitive Dysfunction (genetics)
• Cytokines (genetics)
• Female
• Genotype
• Humans
• Interferon-gamma (genetics)
• Interleukin-10 (genetics)
• Interleukin-6 (genetics)
• Male
• Polymorphism, Single Nucleotide
• Transforming Growth Factor beta1 (genetics)
• Tumor Necrosis Factor-alpha (genetics)