Polymorphisms of Cytokine Genes and Polycystic Ovary Syndrome: A Review.

Abstract

BACKGROUND:

Polycystic ovary syndrome (PCOS) is the endocrinopathy that affects women in their reproductive age. The physiopathology involves multifactorial mechanisms, including cytokine gene regulation.

METHODS:

The review was conducted in the database PubMed, with articles published between 2005 and 2015. The selected studies evaluated the single-nucleotide polymorphisms (SNPs) of cytokines genes in association with PCOS. Twenty-four studies met the inclusion criteria and showed the SNPs of cytokines that were associated or not with PCOS.

RESULTS:

The disease susceptibility was associated with interleukin (IL) 1A, IL1B, IL1RN, and IL6 alleles and genotypes. The tumor necrosis factor (TNF) -1032 C/T genotype and C allele were risk factors and T/T genotype was a protector marker to disease. The IL18 SNPs were not associated with PCOS per se, but IL18-137 C and G alleles were related to the protection of insulin resistance and glucose tolerance, respectively. One research found association between TGFB1 and PCOS. However, the TNF -308, IL10, and interferon (IFN) SNPs did not appear to influence PCOS genetic susceptibility.

CONCLUSIONS:

This study sought to contribute and clarify the SNPs in cytokine genes that influence the development of PCOS. Most studies occurred in Asia; most SNPs studied were in IL1B -511, TNF -1031, and IL6-174; and most of them were associated with the susceptibility to PCOS development. Nevertheless, further investigations based on genome-wide association studies and cytokine gene SNPs are needed to better characterize the risk factors to PCOS.

• Authors: Josiane Bazzo de Alencar, Hugo Vicentin Alves, Laise Nayana Sala Elpidio, Jeane Eliete Laguila Visentainer, Ana Maria Sell
• Journal: Metabolic syndrome and related disorders (Metab Syndr Relat Disord) Vol. 14 Issue 10 Pg. 468-474 (12 2016) ISSN: 1557-8518 [Electronic] United States
• PMID: 27809669 (Publication Type: Journal Article, Review)

Chemical References

• Cytokines

Topics

• Cytokines (genetics)
• Female
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Humans
• Polycystic Ovary Syndrome (epidemiology, genetics)
• Polymorphism, Single Nucleotide