Enhanced activity of anticancer drugs in murine tumours by co-administration with 3-amino-pyrrolidine-2,5-dione-N-mustard derivative.

Abstract

(R,S)3-(N,N-[bis-(2-chloroethyl)]-amino)-1-(2'-methoxyphenyl)- pyrrolidine-2,5-dione hydrochloride (I) has shown antitumor activity against P388 and L1210 leukaemias and Sarcoma 180 (ascites). The effect of (I), when co-administered with anticancer drugs, was studied in these murine tumours. Although co-administration of (I) with methotrexate showed a significant increase of the activity against P388 and L1210 leukaemias and Sarcoma 180 (ascites), co-administration of (I) with 5-fluorouracil, mitomycin C, adriamycin or vincristine did not exhibit any enhancing, synergistic or additive effect in the activity of these drugs.

• Authors: R Y Ambaye, M A Indap, S D Naik
• Journal: Journal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 115 Issue 4 Pg. 379-82 ( 1989) ISSN: 0171-5216 [Print] Germany
• PMID: 2760102 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Nitrogen Mustard Compounds
• Pyrrolidinones
• 3-(N,N-bis(2-chloroethyl)amino)-1-(2'-methoxyphenyl)pyrrolidine-2,5-dione

Topics

• Animals
• Antineoplastic Agents (administration & dosage)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Drug Synergism
• Female
• Male
• Mice
• Mice, Inbred Strains
• Neoplasms, Experimental (drug therapy)
• Nitrogen Mustard Compounds (administration & dosage)
• Pyrrolidinones (administration & dosage)