Novel GM-CSF-based vaccines: One small step in GM-CSF gene optimization, one giant leap for human vaccines.

Abstract

Granulocyte macrophage-colony stimulating factor (GM-CSF) is a potent immunomodulatory cytokine that is known to facilitate vaccine efficacy by promoting the development and prolongation of both humoral and cellular immunity. In the past years we have generated a novel codon-optimized GM-CSF gene as an adjuvant. The codon-optimized GM-CSF gene significantly increased protein expression levels in all cells tested and helped in generating a strong immune responses against HIV-1 Gag and HPV-associated cancer. Here, we review the literature dealing with the adjuvant activity of GM-CSF both in animal models and clinical trials. We anticipate that the codon-optimized GM-CSF gene offers a practical molecular strategy for potentiating immune responses to tumor cell-based vaccinations as well as other immunotherapeutic strategies.

• Authors: Ting-Wei Yu, Ho-Yen Chueh, Ching-Chou Tsai, Cheng-Tao Lin, Jiantai Timothy Qiu
• Journal: Human vaccines & immunotherapeutics (Hum Vaccin Immunother) Vol. 12 Issue 12 Pg. 3020-3028 (12 2016) ISSN: 2164-554X [Electronic] United States
• PMID: 27560197 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)

Chemical References

• AIDS Vaccines
• Adjuvants, Immunologic
• Cancer Vaccines
• Granulocyte-Macrophage Colony-Stimulating Factor

Topics

• AIDS Vaccines (administration & dosage, immunology)
• Adjuvants, Immunologic (administration & dosage, genetics)
• Animals
• Cancer Vaccines (administration & dosage, immunology)
• Clinical Trials as Topic
• Drug Evaluation, Preclinical
• Granulocyte-Macrophage Colony-Stimulating Factor (administration & dosage, genetics)
• Humans
• Models, Animal