Abstract | PURPOSE: METHODS: This is a retrospective analysis of esophageal cancer patients with TBI who received induction chemotherapy. Airway involvement was defined as bronchoscopic appearance of a bulge into the lumen, restricted or immobile mucosa, frank infiltration, TEF, or stridor, which was clinically due to airway obstruction from the esophageal lesion. RESULTS: Eighty-three patients were included over 5 years; 97.6 % had squamous histology. All patients received taxane and platinum combination induction chemotherapy; 90.5 % of patients received chemotherapy without dose delays, and 77.8 % patients did not require a dose reduction or modification. The 31.7 % patients had a clinically significant ≥grade 3 toxicity. The objective response rate was 67 % among the patients who underwent restaging scans following induction chemotherapy; 79.5 % of the patients could receive radical intent therapy, either concurrent chemoradiotherapy, or radiation alone, or surgery in one patient. The TEF complication rate was 6 % during the course of therapy. At a median follow-up of 28 months in surviving patients, the estimated median PFS was 8 months (95 % CI 5.5-10.5) and the estimated median OS was 17 months (95 % CI 5.6-28.4). Patients who received radical therapy had a significantly better PFS and OS, p = 0.000. CONCLUSIONS:
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Authors | Vanita Noronha, Amit Joshi, Vijay M Patil, Nilendu Purandare, Sabita Jiwnani, Sarbani Ghosh-Laskar, Dipti Nakti, Bhavesh Bandekar, Kumar Prabhash |
Journal | Journal of gastrointestinal cancer
(J Gastrointest Cancer)
Vol. 47
Issue 3
Pg. 294-304
(Sep 2016)
ISSN: 1941-6636 [Electronic] United States |
PMID | 27198523
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Bronchi
(pathology)
- Esophageal Neoplasms
(drug therapy, pathology)
- Female
- Humans
- Induction Chemotherapy
(methods)
- Male
- Middle Aged
- Neoplasm Invasiveness
- Retrospective Studies
- Trachea
(pathology)
- Tracheoesophageal Fistula
(pathology)
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