Transforming growth factor-β, interleukin-17, and IL-23 gene expression profiles associated with human peri-implantitis.

Abstract

OBJECTIVES:

The mRNA expression profiles of IL-23/Th17 and the Treg-associated cytokine TGF-β in peri-implantitis are currently under research. This study characterized the IL-17, IL-23, and TGF-β gene expression levels in healthy and diseased peri-implant tissues and correlated these data with radiographic bone loss.

MATERIAL AND METHODS:

Peri-implant soft tissues from 40 subjects (20 healthy controls with mean age of 59.4 ± 6.3, and 20 with peri-implantitis with mean age of 56.6 ± 5.5) were enrolled in this study, and real-time PCR (RT-PCR) was used to define the profile of IL-17, IL-23, and TGF-β gene expression.

RESULTS:

Higher levels of TGF-β mRNA were observed in biopsies taken from healthy controls, and the IL-23 mRNA levels were significantly increased in the peri-implantitis group (P < 0.0001). No differences in IL-17 mRNA levels were observed between the two groups (P > 0.05).

CONCLUSIONS:

Data presented in this report demonstrated a predominant Th17 response in peri-implantitis subjects based on the higher levels of IL-23 and lower levels of TGF-β detected.

• Authors: Gustavo Pereira Mardegan, Jamil Awad Shibli, Leandro Amadeu Roth, Marcelo Faveri, Gabriela Giro, Marta Ferreira Bastos
• Journal: Clinical oral implants research (Clin Oral Implants Res) Vol. 28 Issue 7 Pg. e10-e15 (Jul 2017) ISSN: 1600-0501 [Electronic] Denmark
• PMID: 27062688 (Publication Type: Journal Article)
• Copyright: © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Interleukin-17
• Interleukin-23
• RNA, Messenger
• Transforming Growth Factor beta

Topics

• Biopsy
• Case-Control Studies
• Female
• Gene Expression
• Humans
• Interleukin-17 (genetics)
• Interleukin-23 (genetics)
• Male
• Middle Aged
• Peri-Implantitis (genetics)
• RNA, Messenger (genetics)
• Real-Time Polymerase Chain Reaction
• Transforming Growth Factor beta (genetics)