Increased IL-25 levels in the peritoneal fluid of patients with endometriosis.

Abstract

Previous studies have indicated a higher prevalence of allergic disease among women with endometriosis. It is already well established that type 1 allergies develop in a Th2 cytokine environment. Recent studies have shown, however, that IL-25 induces a Th2 development of naive T lymphocytes and is central in the Th2 response. The aim of this case-control study was to investigate the presence of IL-25 in the peritoneal fluid of women suffering from endometriosis. PF was obtained both from women undergoing laparoscopic surgery due to endometriosis (25 cases) and from women wanting sterilisation (19 controls). IL-25 levels were then investigated by ELISA. Women with endometriosis showed significantly higher levels of IL-25 in their PF (p=0.019) compared to controls. IL-25 levels did not correlate with the stage of endometriosis. Both Th2-cells and mast cells express IL-25, which could favor the development of allergies by perpetuating a hypersensitivity reaction. Further, IL-25 may also hold a role as a diagnostic tool.

• Authors: Helle Folge Bungum, Uffe Nygaard, Christian Vestergaard, Pia M Martensen, Ulla Breth Knudsen
• Journal: Journal of reproductive immunology (J Reprod Immunol) Vol. 114 Pg. 6-9 (Apr 2016) ISSN: 1872-7603 [Electronic] Ireland
• PMID: 26852387 (Publication Type: Clinical Trial, Journal Article, Observational Study)
• Copyright: Copyright © 2016. Published by Elsevier Ireland Ltd.

Chemical References

• IL25 protein, human
• Interleukin-17

Topics

• Adult
• Ascitic Fluid (immunology, metabolism)
• Case-Control Studies
• Endometriosis (immunology, metabolism)
• Female
• Humans
• Interleukin-17 (immunology, metabolism)
• Laparoscopy
• Mast Cells (immunology, metabolism)
• Th2 Cells (immunology, metabolism)