Abstract | PURPOSE: PATIENTS AND METHODS: RESULTS: VPA use at start of chemoradiotherapy was not associated with improved PFS or OS compared with all other patients pooled (PFS: hazard ratio [HR], 0.91; 95% CI, 0.77 to 1.07; P = .241; OS: HR, 0.96; 95% CI, 0.80 to 1.15; P = .633). Furthermore, PFS and OS of patients taking VPA both at start of and still after chemoradiotherapy were not different from those without antiepileptic drug use at both time points (PFS: HR, 0.92; 95% CI, 0.74 to 1.15; P = .467; OS: HR, 1.10; 95% CI, 0.86 to 1.40; P = .440). Similarly, no association with improved outcomes was observed for LEV use. CONCLUSION: The results of this analysis do not justify the use of VPA or LEV for reasons other than seizure control in patients with newly diagnosed glioblastoma outside clinical trials.
|
Authors | Caroline Happold, Thierry Gorlia, Olivier Chinot, Mark R Gilbert, L Burt Nabors, Wolfgang Wick, Stephanie L Pugh, Monika Hegi, Timothy Cloughesy, Patrick Roth, David A Reardon, James R Perry, Minesh P Mehta, Roger Stupp, Michael Weller |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 34
Issue 7
Pg. 731-9
(Mar 01 2016)
ISSN: 1527-7755 [Electronic] United States |
PMID | 26786929
(Publication Type: Journal Article)
|
Copyright | © 2016 by American Society of Clinical Oncology. |
Chemical References |
- Anticonvulsants
- Antineoplastic Agents, Alkylating
- Levetiracetam
- Valproic Acid
- Dacarbazine
- Temozolomide
- Piracetam
|
Topics |
- Adolescent
- Adult
- Aged
- Anticonvulsants
(therapeutic use)
- Antineoplastic Agents, Alkylating
(therapeutic use)
- Brain Neoplasms
(complications, drug therapy)
- Chemoradiotherapy
- Clinical Trials as Topic
- Dacarbazine
(analogs & derivatives, therapeutic use)
- Epilepsy
(drug therapy, etiology)
- Female
- Glioblastoma
(complications, drug therapy)
- Humans
- Levetiracetam
- Male
- Middle Aged
- Piracetam
(analogs & derivatives, therapeutic use)
- Prognosis
- Survival Analysis
- Temozolomide
- Valproic Acid
(therapeutic use)
|