Cytokines profile in hypertensive patients with left ventricular remodeling and dysfunction.

Abstract

There is strong evidence that inflammatory mediators play a key role in the progression to heart failure in patients with systemic hypertension (HTN). The present study aimed to identify a set of cytokines that are associated with early left ventricular (LV) remodeling and dysfunction as captured by echocardiography in patients with HTN in a cross-sectional case-control study nested within the FLEMish study on ENvironment, Genes and Health Outcome. We identified three groups of participants from the cohort: normotensive subjects (normotension; n = 30), HTN with normal LV structure and function (HTN [LV-]; n = 30), and HTN with evidence of adverse LV remodeling (HTN [LV+]; n = 50). We measured cytokines using a 63-plex Luminex platform. Using partial least squares-discriminant analysis, we constructed three latent variables from the measured cytokines that explained 35%-45% of the variance between groups. We identified five common cytokines (interleukin 18, monokine induced by gamma interferon, hepatocyte growth factor, epithelial neutrophil-activating peptide 78, and vascular endothelial growth factor D) with a stable signal which had a major impact on the construction of the latent variables. Among these cytokines, after adjustment for confounders, interleukin 18 remained significantly different between HTN participants with and without LV involvement (P = .02). Moreover, granulocyte-macrophage colony-stimulating factor and leptin showed a consistent upward trend in all HTN patients compared with normotensive subjects. In conclusion, in HTN patients with LV remodeling or/and dysfunction, we identified a set of cytokines strongly associated with LV maladaptation. We also found a distinct profile of inflammatory biomarkers that characterize HTN.

• Authors: Tatiana Kuznetsova, Francois Haddad, Judita Knez, Yael Rosenberg-Hasson, Janine Sung, Nicholas Cauwenberghs, Lutgarde Thijs, Ioannis Karakikes, Holden Maecker, Kenneth W Mahaffey, Joseph C Wu, Jan A Staessen
• Journal: Journal of the American Society of Hypertension : JASH (J Am Soc Hypertens) Vol. 9 Issue 12 Pg. 975-84.e3 (Dec 2015) ISSN: 1878-7436 [Electronic] United States
• PMID: 26565110 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Cytokines

Topics

• Aged
• Biomarkers (blood)
• Case-Control Studies
• Comorbidity
• Cross-Sectional Studies
• Cytokines (blood)
• Disease Progression
• Echocardiography (methods)
• Female
• Humans
• Hypertension (blood, epidemiology, physiopathology)
• Male
• Middle Aged
• Prognosis
• Reference Values
• Risk Assessment
• Ventricular Dysfunction, Left (diagnostic imaging, epidemiology, physiopathology)
• Ventricular Remodeling (physiology)