Abstract | BACKGROUND: RESULTS:
Oxycodone produced a dose-dependent anti-allodynic effect. Co-administration of DM at a dose of 10 mg/kg (i.p.) (DM10) which had no anti-allodynic effect by itself enhanced the acute oxycodone (1 mg/kg, s.c.) effect. When the chronic anti-allodynic effects were examined, co-administration of DM10 also significantly enhanced the oxycodone effect at 3 mg/kg. Furthermore, oxycodone decreased SNL-induced activation of glial cells (astrocytes and microglia) and plasma levels of proinflammatory cytokines (IL-6, IL-1β and TNF-α). Co-administration of DM10 potentiated these effects of oxycodone. CONCLUSION: The combined use of DM with oxycodone may have therapeutic potential for decreasing the effective dose of oxycodone on the treatment of neuropathic pain. Attenuation of the glial activation and proinflammatory cytokines in the spinal cord may be important mechanisms for these effects of DM.
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Authors | Pao-Pao Yang, Geng-Chang Yeh, Eagle Yi-Kung Huang, Ping-Yee Law, Horace H Loh, Pao-Luh Tao |
Journal | Journal of biomedical science
(J Biomed Sci)
Vol. 22
Pg. 81
(Sep 22 2015)
ISSN: 1423-0127 [Electronic] England |
PMID | 26391752
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cytokines
- Dextromethorphan
- Oxycodone
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Topics |
- Animals
- Astrocytes
(metabolism, pathology)
- Cytokines
(metabolism)
- Dextromethorphan
(agonists, pharmacology)
- Disease Models, Animal
- Drug Synergism
- Male
- Mice
- Microglia
(metabolism, pathology)
- Neuralgia
(drug therapy, metabolism, pathology)
- Oxycodone
(agonists, pharmacology)
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