Abstract | BACKGROUND: To investigate stromal variables including angiogenesis, lymphangiogenesis, and matrix metalloproteinase ( MMP) in the serum of patients with urothelial carcinoma of the bladder (UCB) and to evaluate their association with histopathological characteristics and clinical outcome. MATERIAL AND METHODS: RESULTS: A positive association for VEGF-D (p<0.001) and an inverse association for MMP-2 (p=0.017) were observed in patients with positive lymph node (LN) status at the time of RC. VEGF-A (p<0.001), VEGF-C (p<0.001), MMP-2 (p<0.001), and MMP-7 (p=0.005) serum levels were different in serum of patients with invasive UCB compared with non-invasive UCB or healthy individuals. None of the serum markers were associated with disease progression. CONCLUSIONS: High VEGF-D and low MMP-2 serum levels predict LN metastasis in patients with UCB at the time of RC. VEGF-A, VEGF-C, MMP-2, and MMP-7 serum levels varied significantly between invasive and non-invasive disease as well as in comparison with healthy individuals. Clinical implementation of these marker serum measurements may be valuable to select high-risk patients with more invasive or nodal-positive disease.
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Authors | Tobias Benoit, Etienne X Keller, Pirmin Wolfsgruber, Thomas Hermanns, Michele Günthart, Irina Banzola, Tullio Sulser, Maurizio Provenzano, Cédric Poyet |
Journal | Medical science monitor : international medical journal of experimental and clinical research
(Med Sci Monit)
Vol. 21
Pg. 2266-74
(Aug 04 2015)
ISSN: 1643-3750 [Electronic] United States |
PMID | 26241709
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- VEGFD protein, human
- Vascular Endothelial Growth Factor D
- MMP2 protein, human
- Matrix Metalloproteinase 2
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(blood)
- Case-Control Studies
- Female
- Humans
- Lymphatic Metastasis
- Male
- Matrix Metalloproteinase 2
(blood)
- Middle Aged
- Neoplasm Invasiveness
- Predictive Value of Tests
- Prognosis
- Urinary Bladder Neoplasms
(blood, pathology, secondary)
- Vascular Endothelial Growth Factor D
(blood)
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