Abstract | INTRODUCTION: PRESENTATION OF CASE: DISCUSSION: Although, Crohn's disease and colorectal carcinoma association is well established, few cases have been reported where the cancer has originated within a perianal fistula. Constant mucosal regeneration occurring within a fistula seems to be the predominant pathogenetic mechanism, while immunosuppressants and anti-TNF agents may also contribute to the malignant transformation. Unfortunately, the lack of suspicion and the inadequate physical examination or colonoscopy due to exacerbation of the perianal symptoms could lead to delayed diagnosis; and thus, a poor prognosis. CONCLUSION: Albeit a rare complication, clinicians should maintain a high degree of vigilance about the possible development of adenocarcinoma in patients with long-standing perianal Crohn's disease. Thus, these patients should be kept under regular surveillance with examination under anaesthesia and biopsies or curettage of the tracts.
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Authors | Ioannis Papaconstantinou, Dionysios S Mantzos, Agathi Kondi-Pafiti, Ioannis E Koutroubakis |
Journal | International journal of surgery case reports
(Int J Surg Case Rep)
Vol. 10
Pg. 201-3
( 2015)
ISSN: 2210-2612 [Print] Netherlands |
PMID | 25884608
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved. |