Abstract | BACKGROUND AND AIMS:
Multiple sclerosis (MS) is an inflammatory condition of the central nervous system, with genetic and environmental factors having a role in its etiology. The condition is characterized by demyelination, acute inflammation, and chronic and acute lesions in the central nervous system. Human and experimental studies have shown that T-helper cells, and pro-inflammatory cytokines have a major role in the pathogenesis of MS. Recent researches have shown that IL-17 secreting T (Th17) cells have a role in inflammation and demyelination of the central nervous system. In the present study, the role of Interleukin-17A (IL-17A) and Interleukin-17F (IL-17F) in the immunopathogenesis and follow-up of the MS disease was evaluated. MATERIALS AND METHODS: Thirty-five relapsing remitting (RR) form of MS patients were included in the present study. Blood samples were taken from 35 MS patients and 35 healthy individuals as controls. Enzyme-Linked Immunosorbent Assay (ELISA) was used to determine IL-17A and IL-17F serum levels. RESULTS: A statistically significant increase was noted in the serum levels of IL-17A and IL-17F in MS patients compared to the controls (P<0.001). There was a significant positive correlation of IL-17F serum levels with the number of relapses (rs=0.717, P<0.001). However, there was no significant relationship between the serum levels of these cytokines and Expanded Standard Disability Stated Scale (EDSS) and disease Progression Index (PI). CONCLUSION: The data of the present study revealed a significant increase in the serum levels of IL-17A and IL-17F in MS patients compared with healthy controls and a significant positive correlation of IL-17F serum levels with the number of relapses. It appears that increased serum levels of IL-17 and especially IL-17F may lead to a raised risk of MS.
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Authors | Zohreh Babaloo, Mohammad Reza Aliparasti, Farhad Babaiea, Shohreh Almasi, Behzad Baradaran, Mehdi Farhoudi |
Journal | Immunology letters
(Immunol Lett)
Vol. 164
Issue 2
Pg. 76-80
(Apr 2015)
ISSN: 1879-0542 [Electronic] Netherlands |
PMID | 25625963
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015. Published by Elsevier B.V. |
Chemical References |
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Topics |
- Adult
- Case-Control Studies
- Female
- Humans
- Interleukin-17
(blood)
- Male
- Multiple Sclerosis, Relapsing-Remitting
(blood, diagnosis, immunology, metabolism)
- Th17 Cells
(immunology, metabolism)
- Young Adult
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