Brain protection conferred by long-term administration of 2-(2-benzofuranyl)-2-imidazoline against experimental autoimmune encephalomyelitis.
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| Abstract |
Our previous studies showed that 2-(2-benzofuranyl)-2-imidazoline (2-BFI), a ligand to type 2 imidazoline receptor, was protective against brain and spinal cord injury caused by experimental autoimmune encephalomyelitis (EAE). In the present study, we investigated the effect of long-term administration of 2-BFI and the dose-dependent response relationship of long-term administration of 2-BFI with neuroprotection. Treatment with 2-BFI at doses of 5, 10, and 20 mg/kg for 14 days significantly reduced hind limb paralysis and the severity of EAE compared with the EAE control group. Long-term use of 2-BFI was not only safe to mice, but also dose-dependently reduced the expression of inflammatory cytokines, including TNF-α, Interferon-γ and Interleukin-17A, compared with the EAE control group. Expressions of neuronal injury markers, including cytochrome c, AIF and β-APP, were also reduced significantly in response to long-term 2-BFI treatment. Together, these results provided new evidence to demonstrate that 2-BFI is a safe and effective candidate for further development as a therapeutic drug for treatment of multiple sclerosis.
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| Authors | Ying-Biao Zhu, Nian-Ge Xia, Yuan-Tao Zhang, Xin-Shi Wang, Shan-Shan Liang, Wei-Yong Yin, Hui-Qin Xu, Sheng-Tao Hou, Rong-Yuan Zheng |
| Journal | Neurochemical research (Neurochem Res) Vol. 40 Issue 3 Pg. 572-8 (Mar 2015) ISSN: 1573-6903 [Electronic] United States |
| PMID | 25522738 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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