Abstract | RATIONALE: OBJECTIVES: METHODS:
Streptozotocin (3mg/kg, ICV) was injected bilaterally in two divided doses on first and third day followed by treatment with different doses of naringin (50, 100 and 200mg/kg; p.o.) for twenty one days. Behavioral alterations were monitored using Morris water maze paradigm and elevated plus maze test. Animals were sacrificed to evaluate various biochemical and mitochondrial parameters in brain. Rivastigmine was used as a standard drug. RESULTS: ICV-STZ administration produced significant cognitive deficits as assessed by both Morris water maze and elevated plus maze task which is accompanied by significantly enhanced oxidative-nitrosative stress, altered acetylcholinesterase and mitochondrial enzyme activities in cerebral cortex and hippocampus of rats brain along with significantly increased brain TNF-α and IL-1β levels. Chronic treatment with naringin dose dependently restored cognitive deficits in ICV-STZ rat along with mitigation of mitochondrial dysfunction mediated oxido-nitrosative stress and cytokine release. CONCLUSIONS:
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Authors | Anand Kamal Sachdeva, Anurag Kuhad, Kanwaljit Chopra |
Journal | Pharmacology, biochemistry, and behavior
(Pharmacol Biochem Behav)
Vol. 127
Pg. 101-10
(Dec 2014)
ISSN: 1873-5177 [Electronic] United States |
PMID | 25449356
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Alzheimer Disease
(drug therapy, metabolism, psychology)
- Animals
- Dose-Response Relationship, Drug
- Flavanones
(pharmacology, therapeutic use)
- Male
- Memory Disorders
(drug therapy, metabolism, psychology)
- Mitochondria
(drug effects, physiology)
- Random Allocation
- Rats
- Rats, Wistar
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