Abstract | PURPOSE: To analyze inflammatory parameters as possible predictors for the development of uveitis in juvenile idiopathic arthritis (JIA) patients. Further, to analyze the predictive value of demographic and clinical factors at the onset of arthritis. DESIGN: Retrospective cohort study. METHODS: RESULTS: One hundred forty-seven patients (41%) were diagnosed with chronic anterior uveitis. Young age of onset, presence of ANA, and elevated ESR appeared to be predictive factors according to univariate analyses (P = .029, P = .007, and P = 5E(-4), respectively). According to multivariate analysis, young age of onset and elevated ESR appeared to be predictive after adjusting for the other relevant factors (P = .004 and P = .001, respectively). A prediction model was developed. CONCLUSIONS: Elevated ESR appears to be a predictor for the occurrence of uveitis in patients with JIA. Since ESR is already routinely tested in patients with recently diagnosed arthritis, its use as a biomarker can easily be implemented in daily practice.
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Authors | Arenda J W Haasnoot, Maretta van Tent-Hoeve, Nico M Wulffraat, Nicoline E Schalij-Delfos, Leonoor I Los, Wineke Armbrust, Nicolaas P A Zuithoff, Joke H de Boer |
Journal | American journal of ophthalmology
(Am J Ophthalmol)
Vol. 159
Issue 2
Pg. 372-7.e1
(Feb 2015)
ISSN: 1879-1891 [Electronic] United States |
PMID | 25447121
(Publication Type: Journal Article)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Antibodies, Antinuclear
- Biomarkers
- HLA-B27 Antigen
- C-Reactive Protein
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Topics |
- Age of Onset
- Antibodies, Antinuclear
(blood)
- Arthritis, Juvenile
(blood)
- Biomarkers
(blood)
- Blood Sedimentation
- C-Reactive Protein
(metabolism)
- Child
- Child, Preschool
- Cohort Studies
- Female
- HLA-B27 Antigen
(blood)
- Humans
- Infant
- Leukocyte Count
- Male
- Retrospective Studies
- Uveitis
(blood)
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