Abstract | BACKGROUND: Modified Atkins diet is a treatment option for patients with pharmacoresistant epilepsy that is not suitable for surgery. In the last few years, we have tried dietary treatment added to antiepileptic drugs (AEDs) in adult patients with severe epilepsy. AIM OF THE STUDY: To examine a possible pharmacokinetic interaction between the modified Atkins diet and AEDs. METHODS: RESULTS: After 12 weeks on the diet, the average serum concentrations of the respective AEDs were reduced by 35% (range 6-46%) compared to prediet values. CONCLUSIONS: Modified Atkins diet used as add-on therapy to AEDs in four patients with drug resistant seizures caused a considerable decrease in AED serum concentrations. In individual patients, this could be of clinical relevance, and we recommend that AED serum concentrations should be closely monitored when offering this diet to adults with epilepsy.
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Authors | M Kverneland, E Taubøll, K K Selmer, P O Iversen, K O Nakken |
Journal | Acta neurologica Scandinavica
(Acta Neurol Scand)
Vol. 131
Issue 3
Pg. 187-90
(Mar 2015)
ISSN: 1600-0404 [Electronic] Denmark |
PMID | 25312999
(Publication Type: Clinical Trial, Journal Article)
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Copyright | © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
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Topics |
- Adult
- Anticonvulsants
(blood, therapeutic use)
- Diet, Carbohydrate-Restricted
(adverse effects)
- Epilepsy
(diet therapy, drug therapy)
- Female
- Humans
- Male
- Middle Aged
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