Changes in cerebrospinal fluid biomarkers in human herpesvirus-6-associated acute encephalopathy/febrile seizures.

Abstract

To determine the involvement of oxidative stress in the pathogenesis of acute encephalopathy associated with human herpesvirus-6 (HHV-6) infection, we measured the levels of oxidative stress markers 8-hydroxy-2'-deoxyguanosine (8-OHdG) and hexanoyl-lysine adduct (HEL), tau protein, and cytokines in cerebrospinal fluid (CSF) obtained from patients with HHV-6-associated acute encephalopathy (HHV-6 encephalopathy) (n = 16) and complex febrile seizures associated with HHV-6 (HHV-6 complex FS) (n = 10). We also examined changes in CSF-8OHdG and CSF-HEL levels in patients with HHV-6 encephalopathy before and after treatment with edaravone, a free radical scavenger. CSF-8-OHdG levels in HHV-6 encephalopathy and HHV-6 complex FS were significantly higher than in control subjects. In contrast, CSF-HEL levels showed no significant difference between groups. The levels of total tau protein in HHV-6 encephalopathy were significantly higher than in control subjects. In six patients with HHV-6 infection (5 encephalopathy and 1 febrile seizure), the CSF-8-OHdG levels of five patients decreased after edaravone treatment. Our results suggest that oxidative DNA damage is involved in acute encephalopathy associated with HHV-6 infection.

• Authors: Naoyuki Tanuma, Rie Miyata, Keisuke Nakajima, Akihisa Okumura, Masaya Kubota, Shin-ichiro Hamano, Masaharu Hayashi
• Journal: Mediators of inflammation (Mediators Inflamm) Vol. 2014 Pg. 564091 ( 2014) ISSN: 1466-1861 [Electronic] United States
• PMID: 25294958 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• 8-Hydroxy-2'-Deoxyguanosine
• Deoxyguanosine
• Edaravone
• Antipyrine

Topics

• 8-Hydroxy-2'-Deoxyguanosine
• Adolescent
• Antipyrine (analogs & derivatives, therapeutic use)
• Biomarkers (cerebrospinal fluid)
• Child
• DNA Damage (physiology)
• Deoxyguanosine (analogs & derivatives, cerebrospinal fluid)
• Edaravone
• Female
• Herpesvirus 6, Human (pathogenicity)
• Humans
• Male
• Roseolovirus Infections (cerebrospinal fluid, drug therapy, metabolism)
• Seizures, Febrile (drug therapy, metabolism, virology)
• Young Adult