Human herpesvirus 8 (HHV-8) is the etiologic agent of all
Kaposi's sarcoma (KS), the outcome of which is associated with immuno-dysregulation, resulting in the abnormal production of inflammatory
cytokines and
chemokines. We quantified by
enzyme-linked
immunosorbent assay serum levels of
interleukin (IL)-10,
IL-17,
interferon (IFN)-γ, and
tumor necrosis factor (TNF)-α from patients with KS-
AIDS, classic KS, and human immunodeficiency virus (HIV) without KS. A correlation between HHV-8 molecular detection and
cytokine production was also performed. We observed that
IL-10 production was higher in patients with KS-
AIDS when compared to those with classic KS or HIV. However, no significant differences were seen for IFN-γ, TNF-α, or
IL-17 production between studied groups. When patients with KS-
AIDS were analyzed according to lesion topography,
IL-10 levels were higher in patients with disseminated disease than those observed in patients with only cutaneous lesions or cutaneous and digestive and/or respiratory tract lesions. Finally, patients with KS-
AIDS that presented
viral DNA for HHV-8 in serum showed a higher production of
IL-10 when compared with those patients with a negative result for nested polymerase chain reaction for the virus. The results presented here are the first to demonstrate that there exists a stratification of patients with KS-
AIDS according to lesion topography where
IL-10 levels are higher in those individuals with disseminated disease than those with only localized lesions.